Foldit

476: Unsolved Nanog Transcription Factor

Closed since over 14 years ago

Summary

Created: November 04, 2011
Expires: November 14, 2011 at 23:59 UTC
Max points: 100

Description

Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Top groups

11. Russian team 32 pts. 10,730
12. Deleted group pts. 10,635
13. chillerdown 24 pts. 10,627
14. Deleted group pts. 10,589
15. SETI.Germany 18 pts. 10,501
16. Purdue BoilerFolders 16 pts. 10,498
17. Slovak National Team 14 pts. 10,487
18. xkcd 12 pts. 10,439
19. Mmm Helix Fries. 10 pts. 10,304
20. BOINC@Poland 9 pts. 10,183

51. yoyo washington Lv 1 72 pts. 10,593
52. Susume Lv 1 72 pts. 10,592
53. gmn Lv 1 71 pts. 10,591
54. auntdeen Lv 1 71 pts. 10,589
55. philcalhoun Lv 1 70 pts. 10,589
56. malthreSC Lv 1 70 pts. 10,588
57. karstenw Lv 1 69 pts. 10,585
58. jfryk Lv 1 69 pts. 10,579
59. krulon Lv 1 68 pts. 10,577
60. PRL Lv 1 68 pts. 10,573

Comments

beta_helix Staff Lv 1

November 04, 2011

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

woodenjasoon Lv 1

January 17, 2013

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.