476: Unsolved Nanog Transcription Factor

Closed since over 14 years ago

Summary

• Created: November 04, 2011
• Expires: November 14, 2011 at 23:59 UTC
• Max points: 100

Description

Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Top groups

• 21. Natural Abilities 7 pts. 10,143
• 22. Foldit UK 6 pts. 10,130
• 23. Gravity 5 pts. 10,035
• 24. Eὕρηκα! Heureka! 4 pts. 9,966
• 25. Street Smarts 4 pts. 9,957
• 26. Team Germany 3 pts. 9,939
• 27. Team Canada 3 pts. 9,936
• 28. Mojo Risin' 2 pts. 9,885
• 29. HMT heritage 2 pts. 9,855
• 30. CHNO Junkies 1 pt. 9,810

Top soloists

• 1. Coskun 100 pts. 11,001
• 2. TheGUmmer 100 pts. 10,931
• 3. spmm 99 pts. 10,863
• 4. emunch 99 pts. 10,849
• 5. marie_s 98 pts. 10,849
• 6. Leonardo_C 97 pts. 10,842
• 7. NinjaGreg 97 pts. 10,816
• 8. Ch Garnier 96 pts. 10,810
• 9. mimi 95 pts. 10,802
• 10. arcsign 95 pts. 10,800

Comments

[beta_helix]

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

[woodenjasoon]

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.