Foldit

476: Unsolved Nanog Transcription Factor

Closed since over 14 years ago

Intermediate Intermediate Overall Overall Prediction Prediction

Summary

Created: November 04, 2011
Expires: November 14, 2011 at 23:59 UTC
Max points: 100

Description

Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Top groups

41. DSN @ Home 1 pt. 9,294
42. Deleted group pts. 9,271
43. Freedom Folders 1 pt. 9,037
44. Richard Dawkins Foundation 1 pt. 8,989
45. Structuralists 1 pt. 8,907
46. name_in_progress 1 pt. 8,869
47. Hungary 1 pt. 2,250
48. MeetGadget 1 pt. 745
49. 3HelicesBetterThan1 1 pt. 745

421. Lumir Lv 1 3 pts. 9,483
422. hlunsman Lv 1 3 pts. 9,483
423. Cerzax Lv 1 3 pts. 9,483
424. Darkknight900 Lv 1 3 pts. 9,482
425. CKnight Lv 1 2 pts. 9,473
426. ilopez.7 Lv 1 2 pts. 9,471
427. Marodi Lv 1 2 pts. 9,469
428. jasonalwaysready Lv 1 2 pts. 9,467
429. nobby_rob2011 Lv 1 2 pts. 9,466
430. Jedrik Lv 1 2 pts. 9,461

Comments

beta_helix Staff Lv 1

November 04, 2011

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

woodenjasoon Lv 1

January 17, 2013

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.