Foldit

476: Unsolved Nanog Transcription Factor

Closed since over 14 years ago

Summary

Created: November 04, 2011
Expires: November 14, 2011 at 23:59 UTC
Max points: 100

Description

Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Top groups

1. Void Crushers
100 pts. 10,941
2. Contenders 91 pts. 10,904
3. Deleted group pts. 10,842
4. foldeRNA 73 pts. 10,816
5. L'Alliance Francophone 65 pts. 10,810
6. FoldIt@Netherlands 58 pts. 10,795
7. Anthropic Dreams 52 pts. 10,777
8. Go Science 46 pts. 10,756
9. Androids 41 pts. 10,742
10. Bree Fradley Manning 36 pts. 10,737

611. thelarry6626 Lv 1 1 pt. 9,037
612. shamrockveg Lv 1 1 pt. 9,036
613. RadekSz Lv 1 1 pt. 9,036
614. Neurone05 Lv 1 1 pt. 9,036
615. s8867 Lv 1 1 pt. 9,033
616. averroes38 Lv 1 1 pt. 9,032
617. Skilled Sniper Lv 1 1 pt. 9,026
618. tmhyjason Lv 1 1 pt. 9,026
619. LeafSB Lv 1 1 pt. 9,026
620. the paal kaaba Lv 1 1 pt. 9,024

Comments

beta_helix Staff Lv 1

November 04, 2011

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

woodenjasoon Lv 1

January 17, 2013

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.