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499: CASP ROLL Puzzle 3 with Disulfides

Closed since over 14 years ago

Beginner Overall Prediction

Summary

Created
December 23, 2011
Expires
Max points
100
Description

This is a repost of the third CASP ROLL target, R0003. Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them. You can load in your previous solutions from Puzzle 495.

Top groups

  1. Avatar for Czech National Team 31. Czech National Team 1 pt. 8,090
  2. Avatar for Rechenkraft.net 32. Rechenkraft.net 1 pt. 8,045
  3. Avatar for Crunching Family 33. Crunching Family 1 pt. 7,910
  4. Avatar for DSN @ Home 34. DSN @ Home 1 pt. 7,572
  1. Avatar for mottiger 271. mottiger Lv 1 1 pt. 7,706
  2. Avatar for singingmanatee 272. singingmanatee Lv 1 1 pt. 7,687
  3. Avatar for folbet 273. folbet Lv 1 1 pt. 7,648
  4. Avatar for naphead 274. naphead Lv 1 1 pt. 7,639
  5. Avatar for sweetname 275. sweetname Lv 1 1 pt. 7,636
  6. Avatar for ksada 276. ksada Lv 1 1 pt. 7,633
  7. Avatar for L_D_Sh 277. L_D_Sh Lv 1 1 pt. 7,626
  8. Avatar for roman madala 278. roman madala Lv 1 1 pt. 7,625
  9. Avatar for FRed40foldit 279. FRed40foldit Lv 1 1 pt. 7,623
  10. Avatar for EugeneTwo 280. EugeneTwo Lv 1 1 pt. 7,620

Comments

BootsMcGraw Lv 1

If disulfide bridges are considered important in this puzzle, then why are they scored with such small value?

I was able to make a structure with three solid C-C bonds, which I have worked to score only 8479. The three disulfides score six, six, and seven points, respectively. No player I have talked to has managed to get a disulfide scoring more than eight points.

My best score for this puzzle is 8514, some thirty-five points higher. This structure has no disulfides.

Is the scoring on this puzzle hosed? Or have some of the players been able to make decent secondary structures, and score even higher without the bonds?

If the secondary structure predictions show no helices or sheets, then what else is possibly holding this thing together, except for disulfide bridges?

beta_helix Staff Lv 1

As you can see in Puzzle 503 (http://fold.it/portal/node/991538), the server predictions for this target have very few disulfide bonds as well (as did the top scoring solutions for this puzzle).

I definitely am looking forward to seeing what the native looks like for this one, watch there be only 1 Disulfide Bridge!