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499: CASP ROLL Puzzle 3 with Disulfides

Closed since about 14 years ago

Beginner Overall Prediction

Summary

Created
December 23, 2011
Expires
Max points
100
Description

This is a repost of the third CASP ROLL target, R0003. Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them. You can load in your previous solutions from Puzzle 495.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 8,558
  2. Avatar for Contenders 2. Contenders 86 pts. 8,555
  3. Avatar for foldeRNA 3. foldeRNA 74 pts. 8,542
  4. Avatar for Go Science 4. Go Science 63 pts. 8,533
  5. Avatar for Androids 5. Androids 53 pts. 8,527
  6. Avatar for Void Crushers 6. Void Crushers 44 pts. 8,527
  7. Avatar for HMT heritage 7. HMT heritage 37 pts. 8,510
  8. Avatar for Russian team 8. Russian team 31 pts. 8,507
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 25 pts. 8,482
  10. Avatar for Atheists, Skeptics, & Humanists 10. Atheists, Skeptics, & Humanists 21 pts. 8,479
  1. Avatar for Schleicher 121. Schleicher Lv 1 8 pts. 8,373
  2. Avatar for SimplySue 122. SimplySue Lv 1 8 pts. 8,372
  3. Avatar for demeter900 123. demeter900 Lv 1 8 pts. 8,371
  4. Avatar for kevin everington 124. kevin everington Lv 1 8 pts. 8,370
  5. Avatar for strong_base 125. strong_base Lv 1 8 pts. 8,365
  6. Avatar for SouperGenious 126. SouperGenious Lv 1 7 pts. 8,365
  7. Avatar for lamoille 127. lamoille Lv 1 7 pts. 8,361
  8. Avatar for faron4 128. faron4 Lv 1 7 pts. 8,361
  9. Avatar for Close At Hand 129. Close At Hand Lv 1 7 pts. 8,361
  10. Avatar for jheadlee 130. jheadlee Lv 1 7 pts. 8,360

Comments

BootsMcGraw Lv 1

If disulfide bridges are considered important in this puzzle, then why are they scored with such small value?

I was able to make a structure with three solid C-C bonds, which I have worked to score only 8479. The three disulfides score six, six, and seven points, respectively. No player I have talked to has managed to get a disulfide scoring more than eight points.

My best score for this puzzle is 8514, some thirty-five points higher. This structure has no disulfides.

Is the scoring on this puzzle hosed? Or have some of the players been able to make decent secondary structures, and score even higher without the bonds?

If the secondary structure predictions show no helices or sheets, then what else is possibly holding this thing together, except for disulfide bridges?

beta_helix Staff Lv 1

As you can see in Puzzle 503 (http://fold.it/portal/node/991538), the server predictions for this target have very few disulfide bonds as well (as did the top scoring solutions for this puzzle).

I definitely am looking forward to seeing what the native looks like for this one, watch there be only 1 Disulfide Bridge!