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Bonus Symmetry CASP ROLL R0007 Puzzle

Closed since about 14 years ago

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Summary


Created
February 28, 2012
Expires
Max points
100
Description

The CASP ROLL organizers have told us that the native solved structure for R0007 forms "a noncovalent dimer". We are giving you the top 5 Foldit predictions from Puzzle 515, but you will be able to manipulate them as dimers using symmetry. You'll want to turn off all sidechains and visualizations, as this puzzle will likely crash many computers since this was already a large target. You should not spend too much time on this puzzle, it should really just be for fun. Therefore it will only be worth 20 global points.

Top groups


  1. Avatar for HMT heritage 21. HMT heritage 1 pt. 16,100
  2. Avatar for Needles and Pins 22. Needles and Pins 1 pt. 16,056
  3. Avatar for Freedom Folders 23. Freedom Folders 1 pt. 16,029
  4. Avatar for Deleted group 25. Deleted group pts. 15,956
  5. Avatar for Nerdfighters 26. Nerdfighters 1 pt. 15,942
  6. Avatar for Deleted group 27. Deleted group pts. 15,886
  7. Avatar for Gargleblasters 28. Gargleblasters 1 pt. 15,776
  8. Avatar for Amestris Military 29. Amestris Military 1 pt. 15,771
  9. Avatar for Deleted group 30. Deleted group pts. 15,736

  1. Avatar for steamywindow 241. steamywindow Lv 1 1 pt. 15,876
  2. Avatar for Origami314 242. Origami314 Lv 1 1 pt. 15,854
  3. Avatar for Jim Fraser 243. Jim Fraser Lv 1 1 pt. 15,849
  4. Avatar for halvebounty 244. halvebounty Lv 1 1 pt. 15,833
  5. Avatar for Madde 245. Madde Lv 1 1 pt. 15,819
  6. Avatar for jermainiac 246. jermainiac Lv 1 1 pt. 15,816
  7. Avatar for Sadler 247. Sadler Lv 1 1 pt. 15,808
  8. Avatar for jk408 248. jk408 Lv 1 1 pt. 15,804
  9. Avatar for tallguy-13088 249. tallguy-13088 Lv 1 1 pt. 15,804
  10. Avatar for chaos2 250. chaos2 Lv 1 1 pt. 15,802

Comments


beta_helix Staff Lv 1

This is the information given by the CASP organizers:
http://predictioncenter.org/casprol/target.cgi?id=21&view=all

In CASP9 we had to skip these types of targets, because symmetry was not possible with Foldit… but that is no longer the case!

We wanted to give you the opportunity to fold R0007 in the context of a dimer, but we realize that this was already a big protein, and symmetry makes it even bigger.

This is why it is only worth 20 global points, think of it as an "extra credit" puzzle… it's just for fun so don't be too frustrated if it barely runs on your computer.

Some possible hints

I recommend turning off all sidechains, using Cartoon Thin, with Hydro Color and only showing Clashes. (If this is still too slow, you can try using "Line")

Since it forms a dimer, you probably want to look for a hydrophobic patch where the two sections come together. Coloring by Hydro can help you try to get as much orange at the interface.

If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.

Unfortunately this CASP ROLL target is due on March 6th, so it needs to close late on the 5th.

Please have fun with this one!