Placeholder image of a protein
Icon representing a puzzle

566: CASP10 Target T0691

Closed since almost 14 years ago

Intermediate Overall Prediction

Summary

Created
May 30, 2012
Expires
Max points
100
Description

The seventh CASP10 target is not an easy one, as it's 163 residues and we don't have any alignments for the first 18 residues. We are providing you with 5 different templates, but all of them have a similar topology (that we hope is the correct one!). We will provide you with server predictions once they are released. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 10 pts. 10,813
  2. Avatar for Slovak National Team 12. Slovak National Team 8 pts. 10,717
  3. Avatar for SETI.Germany 13. SETI.Germany 6 pts. 10,672
  4. Avatar for Freedom Folders 14. Freedom Folders 4 pts. 10,294
  5. Avatar for 7Monkeys 15. 7Monkeys 3 pts. 10,169
  6. Avatar for Deleted group 16. Deleted group pts. 10,119
  7. Avatar for Piratenpartei Deutschland 17. Piratenpartei Deutschland 2 pts. 9,927
  8. Avatar for Atlanta 18. Atlanta 1 pt. 9,867
  9. Avatar for putting the eat in meat 19. putting the eat in meat 1 pt. 9,720
  10. Avatar for Deleted group 20. Deleted group pts. 9,463
  1. Avatar for Bletchley Park
    1. Bletchley Park Lv 1
    100 pts. 11,760
  2. Avatar for mimi 2. mimi Lv 1 99 pts. 11,701
  3. Avatar for Steven Pletsch 3. Steven Pletsch Lv 1 97 pts. 11,670
  4. Avatar for meatexplosion 4. meatexplosion Lv 1 95 pts. 11,607
  5. Avatar for auntdeen 5. auntdeen Lv 1 94 pts. 11,576
  6. Avatar for spdenne 6. spdenne Lv 1 92 pts. 11,568
  7. Avatar for Ch Garnier 7. Ch Garnier Lv 1 91 pts. 11,561
  8. Avatar for gmn 8. gmn Lv 1 89 pts. 11,536
  9. Avatar for doug.ehlert 9. doug.ehlert Lv 1 88 pts. 11,504
  10. Avatar for mottiger 10. mottiger Lv 1 86 pts. 11,495

Comments

beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=92
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 10, 14 & 15 are highly predicted to be in a helix. However, the Leucines at residues 62, 115, 125 & 127 are predicted to be sheets.
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1gt1
http://www.pdb.org/pdb/explore/explore.do?structureId=1ew3
http://www.pdb.org/pdb/explore/explore.do?structureId=1pm1
http://www.pdb.org/pdb/explore/explore.do?structureId=1gm6
http://www.pdb.org/pdb/explore/explore.do?structureId=3qzk

beta_helix Staff Lv 1

The N-terminal region of this CASP10 target is unaligned to any of the 5 templates we have given you, but it is predicted to be helical.

Here is a hint to easily make a helix (if that is what you want to attempt):

The rebuild tool takes structure assignment into account, so you can set the secondary structure to helix and then Rebuild. Foldit will then make a helix out of that region.