Placeholder image of a protein
Icon representing a puzzle

566: CASP10 Target T0691

Closed since almost 14 years ago

Intermediate Intermediate Overall Overall Prediction Prediction

Summary

Created
May 30, 2012
Expires
Max points
100
Description

The seventh CASP10 target is not an easy one, as it's 163 residues and we don't have any alignments for the first 18 residues. We are providing you with 5 different templates, but all of them have a similar topology (that we hope is the correct one!). We will provide you with server predictions once they are released. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for Eὕρηκα! Heureka! 21. Eὕρηκα! Heureka! 1 pt. 8,980
  2. Avatar for Geekdo 22. Geekdo 1 pt. 8,625
  3. Avatar for Mojo Risin' 23. Mojo Risin' 1 pt. 8,543
  4. Avatar for Biology-4th 24. Biology-4th 1 pt. 7,678
  5. Avatar for BOINC@Poland 25. BOINC@Poland 1 pt. 7,555
  6. Avatar for DSN @ Home 26. DSN @ Home 1 pt. 7,363
  7. Avatar for test_group1 27. test_group1 1 pt. 369
  8. Avatar for Petr 28. Petr 1 pt. 369
  1. Avatar for caglar 91. caglar Lv 1 16 pts. 10,519
  2. Avatar for Deleted player 92. Deleted player pts. 10,496
  3. Avatar for Museka 93. Museka Lv 1 16 pts. 10,496
  4. Avatar for krulon 94. krulon Lv 1 15 pts. 10,488
  5. Avatar for infjamc 95. infjamc Lv 1 15 pts. 10,477
  6. Avatar for gramps 96. gramps Lv 1 15 pts. 10,453
  7. Avatar for Roukess 97. Roukess Lv 1 14 pts. 10,440
  8. Avatar for harp 98. harp Lv 1 14 pts. 10,438
  9. Avatar for ErichVonSterich 99. ErichVonSterich Lv 1 14 pts. 10,435
  10. Avatar for Obliviador 100. Obliviador Lv 1 13 pts. 10,435

Comments

beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=92
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 10, 14 & 15 are highly predicted to be in a helix. However, the Leucines at residues 62, 115, 125 & 127 are predicted to be sheets.
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1gt1
http://www.pdb.org/pdb/explore/explore.do?structureId=1ew3
http://www.pdb.org/pdb/explore/explore.do?structureId=1pm1
http://www.pdb.org/pdb/explore/explore.do?structureId=1gm6
http://www.pdb.org/pdb/explore/explore.do?structureId=3qzk

beta_helix Staff Lv 1

The N-terminal region of this CASP10 target is unaligned to any of the 5 templates we have given you, but it is predicted to be helical.

Here is a hint to easily make a helix (if that is what you want to attempt):

The rebuild tool takes structure assignment into account, so you can set the secondary structure to helix and then Rebuild. Foldit will then make a helix out of that region.