Placeholder image of a protein
Icon representing a puzzle

566: CASP10 Target T0691

Closed since almost 14 years ago

Intermediate Overall Prediction

Summary

Created
May 30, 2012
Expires
Max points
100
Description

The seventh CASP10 target is not an easy one, as it's 163 residues and we don't have any alignments for the first 18 residues. We are providing you with 5 different templates, but all of them have a similar topology (that we hope is the correct one!). We will provide you with server predictions once they are released. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 11,784
  2. Avatar for Deleted group 2. Deleted group pts. 11,670
  3. Avatar for Void Crushers 3. Void Crushers 69 pts. 11,628
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 56 pts. 11,607
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 45 pts. 11,561
  6. Avatar for Go Science 6. Go Science 36 pts. 11,489
  7. Avatar for foldeRNA 7. foldeRNA 29 pts. 11,389
  8. Avatar for HMT heritage 8. HMT heritage 23 pts. 11,215
  9. Avatar for Gargleblasters 9. Gargleblasters 18 pts. 11,052
  10. Avatar for Russian team 10. Russian team 14 pts. 11,027
  1. Avatar for mong_ae 271. mong_ae Lv 1 1 pt. 369
  2. Avatar for momadoc 272. momadoc Lv 1 1 pt. 369
  3. Avatar for test_account1 273. test_account1 Lv 1 1 pt. 369
  4. Avatar for tamirh 274. tamirh Lv 1 1 pt. 369
  5. Avatar for Crashguard303 275. Crashguard303 Lv 1 1 pt. 369
  6. Avatar for cbennetts 276. cbennetts Lv 1 1 pt. 369
  7. Avatar for DarkCookie23 277. DarkCookie23 Lv 1 1 pt. 369
  8. Avatar for CKnight 278. CKnight Lv 1 1 pt. 369
  9. Avatar for velik10 279. velik10 Lv 1 1 pt. 369
  10. Avatar for Ribo-soma 280. Ribo-soma Lv 1 1 pt. 369

Comments

beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=92
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 10, 14 & 15 are highly predicted to be in a helix. However, the Leucines at residues 62, 115, 125 & 127 are predicted to be sheets.
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1gt1
http://www.pdb.org/pdb/explore/explore.do?structureId=1ew3
http://www.pdb.org/pdb/explore/explore.do?structureId=1pm1
http://www.pdb.org/pdb/explore/explore.do?structureId=1gm6
http://www.pdb.org/pdb/explore/explore.do?structureId=3qzk

beta_helix Staff Lv 1

The N-terminal region of this CASP10 target is unaligned to any of the 5 templates we have given you, but it is predicted to be helical.

Here is a hint to easily make a helix (if that is what you want to attempt):

The rebuild tool takes structure assignment into account, so you can set the secondary structure to helix and then Rebuild. Foldit will then make a helix out of that region.