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568: Beginner CASP10 Refinement Puzzle: TR644

Closed since almost 14 years ago

Beginner Overall Prediction

Summary

Created
June 03, 2012
Expires
Max points
100
Description

This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments.

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  1. Avatar for Eori van Alo 311. Eori van Alo Lv 1 1 pt. 10,408
  2. Avatar for olungu 312. olungu Lv 1 1 pt. 10,408
  3. Avatar for iiiice 313. iiiice Lv 1 1 pt. 10,408
  4. Avatar for screech13 314. screech13 Lv 1 1 pt. 10,401
  5. Avatar for Transfat 315. Transfat Lv 1 1 pt. 10,389
  6. Avatar for paulcianci 316. paulcianci Lv 1 1 pt. 10,366
  7. Avatar for envrsci 317. envrsci Lv 1 1 pt. 10,364
  8. Avatar for darioarena 318. darioarena Lv 1 1 pt. 10,318
  9. Avatar for JGbxl 319. JGbxl Lv 1 1 pt. 10,291
  10. Avatar for porrengia 320. porrengia Lv 1 1 pt. 10,282

Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix went, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

beta_helix Staff Lv 1

We believe that SAM-T08-server_TS1.pdb is identical to the refinement model (except that it obviously doesn't have the first 25 residues trimmed!).