Placeholder image of a protein
Icon representing a puzzle

568: Beginner CASP10 Refinement Puzzle: TR644

Closed since almost 14 years ago

Beginner Overall Prediction

Summary

Created
June 03, 2012
Expires
Max points
100
Description

This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments.

Top groups

  1. Avatar for CHNO Junkies 21. CHNO Junkies 1 pt. 11,111
  2. Avatar for Folding on Linux 22. Folding on Linux 1 pt. 11,058
  3. Avatar for Minions of TWIS 23. Minions of TWIS 1 pt. 11,049
  4. Avatar for Androids 24. Androids 1 pt. 11,037
  5. Avatar for Geekdo 25. Geekdo 1 pt. 11,022
  6. Avatar for Biology-4th 26. Biology-4th 1 pt. 11,012
  7. Avatar for DSN @ Home 27. DSN @ Home 1 pt. 10,908
  8. Avatar for Czech National Team 28. Czech National Team 1 pt. 10,894
  9. Avatar for Crunching Family 29. Crunching Family 1 pt. 10,880
  10. Avatar for Team Canada 30. Team Canada 1 pt. 10,868
  1. Avatar for djag 151. djag Lv 1 6 pts. 11,180
  2. Avatar for versat82 152. versat82 Lv 1 6 pts. 11,179
  3. Avatar for boiled 153. boiled Lv 1 6 pts. 11,177
  4. Avatar for Anathael 154. Anathael Lv 1 6 pts. 11,177
  5. Avatar for Jean-Bob 155. Jean-Bob Lv 1 6 pts. 11,172
  6. Avatar for SouperGenious 156. SouperGenious Lv 1 6 pts. 11,171
  7. Avatar for duran2101 157. duran2101 Lv 1 5 pts. 11,170
  8. Avatar for katling 158. katling Lv 1 5 pts. 11,165
  9. Avatar for AIDA64 159. AIDA64 Lv 1 5 pts. 11,163
  10. Avatar for caglar 160. caglar Lv 1 5 pts. 11,151

Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix went, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

beta_helix Staff Lv 1

We believe that SAM-T08-server_TS1.pdb is identical to the refinement model (except that it obviously doesn't have the first 25 residues trimmed!).