Placeholder image of a protein
Icon representing a puzzle

568: Beginner CASP10 Refinement Puzzle: TR644

Closed since almost 14 years ago

Beginner Overall Prediction

Summary

Created
June 03, 2012
Expires
Max points
100
Description

This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 11,748
  2. Avatar for Void Crushers 2. Void Crushers 85 pts. 11,710
  3. Avatar for Gargleblasters 3. Gargleblasters 72 pts. 11,709
  4. Avatar for Go Science 4. Go Science 61 pts. 11,708
  5. Avatar for HMT heritage 5. HMT heritage 51 pts. 11,697
  6. Avatar for Contenders 6. Contenders 42 pts. 11,669
  7. Avatar for foldeRNA 7. foldeRNA 35 pts. 11,660
  8. Avatar for Deleted group 8. Deleted group pts. 11,642
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 23 pts. 11,615
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 19 pts. 11,545
  1. Avatar for deLaCeiba 201. deLaCeiba Lv 1 2 pts. 11,036
  2. Avatar for Poty 202. Poty Lv 1 2 pts. 11,035
  3. Avatar for mirjamvandelft 203. mirjamvandelft Lv 1 2 pts. 11,029
  4. Avatar for Hyacinth04 204. Hyacinth04 Lv 1 2 pts. 11,029
  5. Avatar for KingLear 205. KingLear Lv 1 2 pts. 11,027
  6. Avatar for dbuske 206. dbuske Lv 1 2 pts. 11,022
  7. Avatar for jjhyde54 207. jjhyde54 Lv 1 2 pts. 11,022
  8. Avatar for alegra 208. alegra Lv 1 2 pts. 11,018
  9. Avatar for steveB 209. steveB Lv 1 1 pt. 11,016
  10. Avatar for sblowers 210. sblowers Lv 1 1 pt. 11,015

Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix went, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

beta_helix Staff Lv 1

We believe that SAM-T08-server_TS1.pdb is identical to the refinement model (except that it obviously doesn't have the first 25 residues trimmed!).