Placeholder image of a protein
Icon representing a puzzle

568: Beginner CASP10 Refinement Puzzle: TR644

Closed since almost 14 years ago

Beginner Overall Prediction

Summary

Created
June 03, 2012
Expires
Max points
100
Description

This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 11,748
  2. Avatar for Void Crushers 2. Void Crushers 85 pts. 11,710
  3. Avatar for Gargleblasters 3. Gargleblasters 72 pts. 11,709
  4. Avatar for Go Science 4. Go Science 61 pts. 11,708
  5. Avatar for HMT heritage 5. HMT heritage 51 pts. 11,697
  6. Avatar for Contenders 6. Contenders 42 pts. 11,669
  7. Avatar for foldeRNA 7. foldeRNA 35 pts. 11,660
  8. Avatar for Deleted group 8. Deleted group pts. 11,642
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 23 pts. 11,615
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 19 pts. 11,545
  1. Avatar for Chaperone11235813 261. Chaperone11235813 Lv 1 1 pt. 10,870
  2. Avatar for Bearpaw 262. Bearpaw Lv 1 1 pt. 10,868
  3. Avatar for Pio456 263. Pio456 Lv 1 1 pt. 10,864
  4. Avatar for biomisha 264. biomisha Lv 1 1 pt. 10,863
  5. Avatar for Savas 265. Savas Lv 1 1 pt. 10,860
  6. Avatar for Maciej.k 266. Maciej.k Lv 1 1 pt. 10,858
  7. Avatar for Blizko 267. Blizko Lv 1 1 pt. 10,854
  8. Avatar for dmuhonen 268. dmuhonen Lv 1 1 pt. 10,853
  9. Avatar for mrjiaruiwang 269. mrjiaruiwang Lv 1 1 pt. 10,848
  10. Avatar for KingPin0 270. KingPin0 Lv 1 1 pt. 10,848

Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix went, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

beta_helix Staff Lv 1

We believe that SAM-T08-server_TS1.pdb is identical to the refinement model (except that it obviously doesn't have the first 25 residues trimmed!).