Placeholder image of a protein
Icon representing a puzzle

568 (<150): Beginner CASP10 Refinement Puzzle: TR644

Closed since almost 14 years ago

Beginner Beginner

Summary

Created
June 03, 2012
Expires
Max points
100
Description

This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 150 global points.

Top groups

  1. Avatar for Deleted group
    1. Deleted group
    pts. 11,631
  2. Avatar for foldeRNA 2. foldeRNA 71 pts. 11,381
  3. Avatar for 7Monkeys 3. 7Monkeys 49 pts. 11,269
  4. Avatar for EasternBlotter 4. EasternBlotter 33 pts. 11,169
  5. Avatar for Minions of TWIS 5. Minions of TWIS 22 pts. 11,159
  6. Avatar for Deleted group 6. Deleted group pts. 11,114
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 8 pts. 11,031
  8. Avatar for Biology-4th 8. Biology-4th 5 pts. 11,015
  9. Avatar for SETI.Germany 9. SETI.Germany 3 pts. 10,998
  10. Avatar for DSN @ Home 10. DSN @ Home 2 pts. 10,983
  1. Avatar for featherwolf 101. featherwolf Lv 1 1 pt. 10,808
  2. Avatar for xiaodeyongerik 102. xiaodeyongerik Lv 1 1 pt. 10,804
  3. Avatar for MsHumptey 103. MsHumptey Lv 1 1 pt. 10,801
  4. Avatar for rustiphor 104. rustiphor Lv 1 1 pt. 10,800
  5. Avatar for yasonthefirst 105. yasonthefirst Lv 1 1 pt. 10,799
  6. Avatar for Cedrie 106. Cedrie Lv 1 1 pt. 10,797
  7. Avatar for andreneumann 107. andreneumann Lv 1 1 pt. 10,781
  8. Avatar for bellr 108. bellr Lv 1 1 pt. 10,777
  9. Avatar for jessielulu 109. jessielulu Lv 1 1 pt. 10,774
  10. Avatar for Anony me 110. Anony me Lv 1 1 pt. 10,772

Comments

beta_helix Staff Lv 1

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix goes, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure: