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583: Large CASP10 Refinement Puzzle: TR689

Closed since almost 14 years ago

Intermediate Intermediate Overall Overall Prediction Prediction

Summary

Created
June 24, 2012
Expires
Max points
100
Description

The seventh CASP10 Refinement Target has 234 residues! This model was the best server prediction for target T0689, generated by the Jiang_Fold server. We've been told that ~87% of this model matches the native, so you just need to find which 13% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.

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Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=132

Note that the organizers gave us this hint:

"Starting model GDT_TS=87."

GDT_TS=87 essentially means that 87% of the model superimposes correctly onto the native structure:

We believe that Jiang_Fold_TS1.pdb is identical to the refinement model.

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 34, 49, 54, 57, 66, 71 & 183 are highly predicted to be in sheets. However, the Valines at residues 3, 107, 137 & 144 are predicted to be anything.

spmm Lv 1

Just a note - on an ok machine (i7-720QM) with 8GB RAM, foldit and a browser running it is taking 6-7 minutes to run Blue Fuse.