Placeholder image of a protein
Icon representing a puzzle

583: Large CASP10 Refinement Puzzle: TR689

Closed since over 13 years ago

Intermediate Overall Prediction

Summary

Created
June 24, 2012
Expires
Max points
100
Description

The seventh CASP10 Refinement Target has 234 residues! This model was the best server prediction for target T0689, generated by the Jiang_Fold server. We've been told that ~87% of this model matches the native, so you just need to find which 13% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 14,390
  2. Avatar for Void Crushers 2. Void Crushers 84 pts. 14,362
  3. Avatar for Beta Folders 3. Beta Folders 70 pts. 14,351
  4. Avatar for Contenders 4. Contenders 58 pts. 14,334
  5. Avatar for Go Science 5. Go Science 48 pts. 14,332
  6. Avatar for HMT heritage 6. HMT heritage 39 pts. 14,287
  7. Avatar for foldeRNA 7. foldeRNA 32 pts. 14,266
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 26 pts. 14,176
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 20 pts. 14,110
  10. Avatar for Androids 10. Androids 16 pts. 14,039
  1. Avatar for martinzblavy 41. martinzblavy Lv 1 48 pts. 14,124
  2. Avatar for Deleted player 42. Deleted player pts. 14,117
  3. Avatar for Jajaboman 43. Jajaboman Lv 1 46 pts. 14,110
  4. Avatar for Tyggy Too 44. Tyggy Too Lv 1 45 pts. 14,098
  5. Avatar for O Seki To 45. O Seki To Lv 1 44 pts. 14,097
  6. Avatar for goastano 46. goastano Lv 1 43 pts. 14,064
  7. Avatar for Timo van der Laan 47. Timo van der Laan Lv 1 42 pts. 14,063
  8. Avatar for bamh 48. bamh Lv 1 42 pts. 14,063
  9. Avatar for keithv 49. keithv Lv 1 41 pts. 14,062
  10. Avatar for Flagg65a 50. Flagg65a Lv 1 40 pts. 14,061

Comments

beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=132

Note that the organizers gave us this hint:

"Starting model GDT_TS=87."

GDT_TS=87 essentially means that 87% of the model superimposes correctly onto the native structure:

We believe that Jiang_Fold_TS1.pdb is identical to the refinement model.

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 34, 49, 54, 57, 66, 71 & 183 are highly predicted to be in sheets. However, the Valines at residues 3, 107, 137 & 144 are predicted to be anything.

spmm Lv 1

Just a note - on an ok machine (i7-720QM) with 8GB RAM, foldit and a browser running it is taking 6-7 minutes to run Blue Fuse.