Placeholder image of a protein
Icon representing a puzzle

588: Normal Start CASP10 Refinement Puzzle: TR679

Closed since over 13 years ago

Intermediate Overall Prediction

Summary

Created
June 29, 2012
Expires
Max points
100
Description

This is the original model given to us by CASP for the same target used in Puzzle 584. They have told us that 3 regions are "showing significant deviation", so please focus on changing the structure of those regions (highlighted in note mode). We've been told that ~72% of this model matches the native, so you shouldn't change the rest of the protein much. Much more info in the comments.

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 13,225
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 81 pts. 13,190
  3. Avatar for Contenders 3. Contenders 65 pts. 13,168
  4. Avatar for Go Science 4. Go Science 52 pts. 13,155
  5. Avatar for foldeRNA 5. foldeRNA 41 pts. 13,101
  6. Avatar for FoldIt@Netherlands 6. FoldIt@Netherlands 32 pts. 13,071
  7. Avatar for Russian team 7. Russian team 24 pts. 13,059
  8. Avatar for Void Crushers 8. Void Crushers 18 pts. 13,014
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 14 pts. 12,984
  10. Avatar for Freedom Folders 10. Freedom Folders 10 pts. 12,716
  1. Avatar for Flagg65a 41. Flagg65a Lv 1 38 pts. 12,869
  2. Avatar for lamoille 42. lamoille Lv 1 37 pts. 12,861
  3. Avatar for rsosborne 43. rsosborne Lv 1 36 pts. 12,853
  4. Avatar for Ignacio 44. Ignacio Lv 1 35 pts. 12,843
  5. Avatar for randomlil 45. randomlil Lv 1 34 pts. 12,834
  6. Avatar for mitarcher 46. mitarcher Lv 1 33 pts. 12,833
  7. Avatar for phi16 47. phi16 Lv 1 32 pts. 12,832
  8. Avatar for martinzblavy 48. martinzblavy Lv 1 31 pts. 12,832
  9. Avatar for Mike Cassidy 49. Mike Cassidy Lv 1 30 pts. 12,824
  10. Avatar for reefyrob 50. reefyrob Lv 1 29 pts. 12,819

Comments

beta_helix Staff Lv 1

If you looked at the recent Gallery Puzzles for the recently released natives:
http://fold.it/portal/node/993060
http://fold.it/portal/node/993059
you will have noticed that the native structures are not very different from the starting models.

This was pointed out in the feedback:
http://fold.it/portal/node/993063

Because of this, for the already difficult refinement target TR679 we are giving you the starting RosettaServer model without modifications for a whole week (instead of a quick puzzle just before the deadline).

We realize that it might be difficult to get this model out of its local minimum, since it has already been minimized by Rosetta.
We hope that if you focus on improving those 3 regions first (residues 25-45, 146-156, 187-197), rather than trying to reach the highest score with the starting topology, you'll eventually be able to reach higher scores by getting closer to the native.

We tried to find a non-Rosetta server model that was close enough to this starting model, but they were all over 2.8 Angtroms away from it!

We have to post both this puzzle and Puzzle 584 at the same time so that we have enough time to send your solutions to the WeFold project.

We posted the starting model in the Alignment Tool so you can use cutpoints and partial threading.

More info about this target (including secondary structure predictions) can be found here:
http://fold.it/portal/node/993026#comment-18444

Last note, remember that you can now turn off the notes in the Selection Interface using the devprev client.