591: Beginner CASP10 Refinement Puzzle: TR671

Closed since over 13 years ago

Summary

• Created: July 04, 2012
• Expires: July 12, 2012 at 07:00 UTC
• Max points: 100

Description

This is the tenth CASP10 Refinement Target. This model was the best server prediction for target T0671, generated by the MUFOLD-Server. We've been told that only ~55% of this model matches the native, so (unlike previous CASP10 refinement puzzles) you'll need to significantly change the starting model. Luckily, this is a short target with only 88 residues. More info in the puzzle comments.

Top groups

• 1. Anthropic Dreams 100 pts. 10,163
• 2. HMT heritage 84 pts. 10,128
• 3. Contenders 70 pts. 10,099
• 4. Beta Folders 57 pts. 10,090
• 5. Go Science 47 pts. 10,064
• 6. Void Crushers 38 pts. 10,055
• 7. foldeRNA 30 pts. 10,054
• 8. FoldIt@Netherlands 24 pts. 10,050
• 9. Atlanta 19 pts. 9,949
• 10. L'Alliance Francophone 15 pts. 9,913

Top soloists

• 21. martinzblavy 71 pts. 10,001
• 22. gramps 69 pts. 9,999
• 23. hansvandenhof 68 pts. 9,992
• 24. spdenne 67 pts. 9,992
• 25. ViJay7019 66 pts. 9,992
• 26. auntdeen 65 pts. 9,990
• 27. Aubade00 63 pts. 9,989
• 28. tallguy-13088 62 pts. 9,985
• 29. Deleted player pts. 9,977
• 30. Bletchley Park 60 pts. 9,967

Comments

[beta_helix]

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=152

Note that the organizers gave us this hint:

"Starting model GDT_TS=55."

GDT_TS=55 essentially means that ONLY 55% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...

Secondary Structure Predictions below:

[beta_helix]

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 40, 52, 73 & 86 are highly predicted to be part of a sheet. However, the Valine at residue 9 is predicted to be in anything.