598: CASP10 Refinement Puzzle: TR712

Closed since over 13 years ago

Summary

• Created: July 10, 2012
• Expires: July 22, 2012 at 04:00 UTC
• Max points: 100

Description

This is the eleventh CASP10 Refinement Target. This model was the best server prediction for target T0712, generated by the MUFOLD-Server. We've been told that ~92% of this model matches the native! So (for once) you won't need to change the starting model much. In addition, the organizers have told us "Regions worth specific attention: 43-52, 79-92, 104-118." These are highlighted in Note Mode.

Top groups

• 11. Richard Dawkins Foundation 9 pts. 12,663
• 12. FoldIt@Netherlands 7 pts. 12,655
• 13. Deleted group pts. 12,620
• 14. Freedom Folders 4 pts. 12,567
• 15. 7Monkeys 3 pts. 12,551
• 16. Deleted group pts. 12,504
• 17. Gargleblasters 1 pt. 12,504
• 18. Piratenpartei Deutschland 1 pt. 12,419
• 19. Natural Abilities 1 pt. 12,406
• 20. Mojo Risin' 1 pt. 12,377

Top soloists

• 111. Mark- 3 pts. 12,473
• 112. infjamc 3 pts. 12,469
• 113. nemo7731 3 pts. 12,468
• 114. tscherulli 3 pts. 12,444
• 115. dembones 3 pts. 12,432
• 116. gdnskye 3 pts. 12,429
• 117. Museka 3 pts. 12,426
• 118. reefyrob 3 pts. 12,426
• 119. versat82 2 pts. 12,419
• 120. Deleted player pts. 12,417

Comments

[beta_helix]

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=170

Note that the organizers gave us this hint:

"Starting model GDT_TS=92. Regions worth specific attention: 43-52, 79-92, 104-118."

GDT_TS=92 essentially means that 92% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 18, 20, 42 & 148 are highly predicted to be part of a sheet. However, the Valine at residue 105 is predicted to be in anything.