Placeholder image of a protein
Icon representing a puzzle

596: CASP10 Target T0740

Closed since over 13 years ago

Advanced Overall Prediction

Summary

Created
July 11, 2012
Expires
Max points
100
Description

The fourteenth CASP10 target is another big one: 165 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 4 different templates (in hope that one of them is correct) for now, and will provide you with some server predictions soon. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 15 pts. 11,013
  2. Avatar for Natural Abilities 12. Natural Abilities 12 pts. 11,006
  3. Avatar for Gargleblasters 13. Gargleblasters 9 pts. 10,949
  4. Avatar for SETI.Germany 14. SETI.Germany 7 pts. 10,868
  5. Avatar for Deleted group 15. Deleted group pts. 10,765
  6. Avatar for Needles and Pins 16. Needles and Pins 4 pts. 10,696
  7. Avatar for 7Monkeys 17. 7Monkeys 3 pts. 10,607
  8. Avatar for Freedom Folders 18. Freedom Folders 2 pts. 10,539
  9. Avatar for Androids 19. Androids 2 pts. 10,352
  10. Avatar for Atlanta 20. Atlanta 1 pt. 10,335
  1. Avatar for jecauril 51. jecauril Lv 1 38 pts. 11,086
  2. Avatar for enszyme 52. enszyme Lv 1 37 pts. 11,083
  3. Avatar for marie_s 53. marie_s Lv 1 36 pts. 11,078
  4. Avatar for bendbob 54. bendbob Lv 1 36 pts. 11,074
  5. Avatar for Deleted player 55. Deleted player pts. 11,069
  6. Avatar for ErichVonSterich 56. ErichVonSterich Lv 1 34 pts. 11,048
  7. Avatar for Jim Fraser 57. Jim Fraser Lv 1 33 pts. 11,033
  8. Avatar for eikem 58. eikem Lv 1 33 pts. 11,028
  9. Avatar for rsosborne 59. rsosborne Lv 1 32 pts. 11,025
  10. Avatar for Antibrad 60. Antibrad Lv 1 31 pts. 11,022

Comments

beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=165
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 106 & 141 are highly predicted to be in a helix. However, the Leucine at residue 115 is predicted to be in a sheet.

NOTE THAT THIS SECONDARY STRUCTURE PREDICTION IS OBVIOUSLY NOT 100% correct, since it is impossible to have a protein with a single sheet.
Clearly there is either another strand or there are no sheets at all!
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1aep
http://www.pdb.org/pdb/explore/explore.do?structureId=2eh3
http://www.pdb.org/pdb/explore/explore.do?structureId=2gyq
http://www.pdb.org/pdb/explore/explore.do?structureId=1yvi

tamirh Lv 1

It's showing up for me in my devprev client. Is anyone else on devprev having this issue?

Have you tried restarting the client(s)? If your connection got temporarily lost it could have not downloaded the new list correctly.