601 (<15): CASP10 Refinement Puzzle: TR723

Closed since over 13 years ago

Summary

• Created: July 15, 2012
• Expires: July 28, 2012 at 23:00 UTC
• Max points: 100

Description

This is the twelfth CASP10 Refinement Target. This model was the best server prediction for target T0723, generated by the Matrix server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 15 global points.

Top groups

• 1. Anthropic Dreams 100 pts. 10,883
• 2. Cannabis Crew 63 pts. 10,786
• 3. :) 37 pts. 10,516
• 4. The Enlightened Flamingoes 21 pts. 10,499
• 5. Androids 11 pts. 10,449
• 6. Friday Lab 5 pts. 10,413
• 7. null pointer exception 2 pts. 10,354
• 8. 7Monkeys 1 pt. 10,335
• 9. Truman College 1 pt. 9,243
• 10. L'Alliance Francophone 1 pt. 8,364

Top soloists

• 121. firelocust 14 pts. 10,374
• 122. Zillo 13 pts. 10,374
• 123. tri 13 pts. 10,373
• 124. jfishjosh 13 pts. 10,373
• 125. ProteinShake71 13 pts. 10,372
• 126. mythorath 12 pts. 10,370
• 127. Frank D. Dunleavy 12 pts. 10,369
• 128. depressad 12 pts. 10,368
• 129. Angel006 12 pts. 10,367
• 130. mburns 11 pts. 10,364

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=173

Note that the organizers gave us this hint:

"Starting model GDT_TS=85."

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...