603 (<15): CASP10 Refinement Puzzle: TR705

Closed since over 13 years ago

Summary

• Created: July 22, 2012
• Expires: July 31, 2012 at 16:00 UTC
• Max points: 100

Description

This is the thirteenth CASP10 Refinement Target. This model was the best server prediction for target T0705, generated by the AOBA-server. We've been told that ~65% of this model matches the native, so you'll need to significantly change the starting model. Luckily, this is a short target with only 96 residues. Note: Cut Tool is available on this puzzle. For players with fewer than 15 global points.

Top groups

• 1. Friday Lab 100 pts. 9,278
• 2. :) 4 pts. 9,266
• 3. Geekdo 2 1 pt. 9,190

Top soloists

• 31. Boxingjay 22 pts. 9,276
• 32. Nanouk 20 pts. 9,272
• 33. PlusAndMinus 19 pts. 9,271
• 34. machinelves 18 pts. 9,266
• 35. djbrown79 17 pts. 9,250
• 36. tonymalva 16 pts. 9,247
• 37. Deleted player 15 pts. 9,240
• 38. leslieisme 14 pts. 9,240
• 39. mythorath 13 pts. 9,238
• 40. jedslater 12 pts. 9,233

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=192

Note that the organizers gave us this hint:

"Starting model GDT_TS=65."

GDT_TS=65 essentially means that ONLY 65% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...