Placeholder image of a protein
Icon representing a puzzle

605: CASP10 Refinement Puzzle: TR710

Closed since almost 14 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction

Summary

Created
July 23, 2012
Expires
Max points
100
Description

This is the fifteenth CASP10 Refinement Target. We've been told that about 75% of this model matches the native, so you'll need to refine ~25% of the structure! More info in the puzzle comments.

Top groups

  1. Avatar for Czech National Team 21. Czech National Team 1 pt. 12,353
  2. Avatar for Skeptics Guide to the Universe 22. Skeptics Guide to the Universe 1 pt. 12,264
  3. Avatar for Friday Lab 23. Friday Lab 1 pt. 12,179
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 12,149
  1. Avatar for ourtown 141. ourtown Lv 1 1 pt. 12,540
  2. Avatar for smileyfuntime 142. smileyfuntime Lv 1 1 pt. 12,533
  3. Avatar for Schleicher 143. Schleicher Lv 1 1 pt. 12,533
  4. Avatar for zerofayt 144. zerofayt Lv 1 1 pt. 12,532
  5. Avatar for phallicies 145. phallicies Lv 1 1 pt. 12,532
  6. Avatar for mitarcher 146. mitarcher Lv 1 1 pt. 12,528
  7. Avatar for rinze 147. rinze Lv 1 1 pt. 12,519
  8. Avatar for LynnNewton 148. LynnNewton Lv 1 1 pt. 12,510
  9. Avatar for impixi 149. impixi Lv 1 1 pt. 12,489
  10. Avatar for Squirrely 150. Squirrely Lv 1 1 pt. 12,484

Comments

beta_helix Staff Lv 1

Please note that the Cut Tool is available on this puzzle!

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=188

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=75."

GDT_TS=75 essentially means that 75% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 19, 52, 85, 145 & 177 are highly predicted to be part of a helix. However, the Valines at residues 96 & 100 are not.