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609: Beginner CASP10 Refinement Puzzle: TR696

Closed since over 13 years ago

Beginner Overall Prediction

Summary

Created
July 30, 2012
Expires
Max points
100
Description

This is the nineteenth CASP10 Refinement Target. This model was the best server prediction for target T0696, generated by the Bilab-Enable server. We've been told that ~71% of this model matches the native, so you just need to find which 29% to refine! Luckily, this is a short target with only 100 residues. More info in the puzzle comments.

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  7. Avatar for Vie 187. Vie Lv 1 1 pt. 9,286
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  9. Avatar for kdieber 189. kdieber Lv 1 1 pt. 9,262
  10. Avatar for caudula 190. caudula Lv 1 1 pt. 9,260

Comments

beta_helix Staff Lv 1

NOTE: The Cut Tool IS available for this puzzle, but only in the Developer Preview.
(If you want to try it out, please read "How do I try out the Foldit Developer Preview?" in the FAQ: http://fold.it/portal/info/faq )
Once the next update posts (early next week) the Cut Tool will be available in main.
__________________

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=196

Note that the organizers gave us this hint:

"Starting model GDT_TS=71."

GDT_TS=71 essentially means that ONLY 71% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valine at residue 19 is highly predicted to be part of a helix. However, the Valine at residue 92 is highly predicted to be in a sheet.