610: CASP10 Refinement Puzzle: TR750

Closed since over 13 years ago

Summary

• Created: August 01, 2012
• Expires: August 11, 2012 at 03:00 UTC
• Max points: 100

Description

This is the twentieth CASP10 Refinement Target. We've been told that ~77% of this model matches the native, so you'll need to refine ~23% of the structure! More info in the puzzle comments.

Top groups

• 11. Gargleblasters 5 pts. 12,047
• 12. HMT heritage 4 pts. 12,043
• 13. SETI.Germany 2 pts. 11,670
• 14. Deleted group pts. 11,663
• 15. Natural Abilities 1 pt. 11,633
• 16. Mojo Risin' 1 pt. 11,239
• 17. Brony@Home 1 pt. 11,183
• 18. Czech National Team 1 pt. 11,031
• 19. Team Canada 1 pt. 10,911
• 20. DSN @ Home 1 pt. 10,721

Top soloists

• 21. PRL 60 pts. 12,189
• 22. phi16 59 pts. 12,188
• 23. christioanchauvin 57 pts. 12,179
• 24. cobaltteal 55 pts. 12,178
• 25. ViJay7019 54 pts. 12,177
• 26. doug.ehlert 53 pts. 12,175
• 27. AsDawnBreaks 51 pts. 12,166
• 28. Timo van der Laan 50 pts. 12,154
• 29. mimi 48 pts. 12,153
• 30. pvc78 47 pts. 12,140

Comments

[beta_helix]

Please note that the Cut Tool is available on all puzzles from now on!

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=202

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=77."

GDT_TS=77 essentially means that 77% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 84 & 176 are highly predicted to be part of a helix. However, the Valines at residues 64-65 & 99 are predicted to be part of a sheet.