Placeholder image of a protein
Icon representing a puzzle

611: CASP10 Refinement Puzzle: TR752

Closed since over 13 years ago

Intermediate Overall Prediction

Summary

Created
August 02, 2012
Expires
Max points
100
Description

This is the twenty-first CASP10 Refinement Target. This model was the best server prediction for target T0752, generated by the BAKER-ROSETTASERVER (using Rosetta@home). We've been told that ~90% of this model matches the native! So (for once) you won't need to change the starting model much. In addition, the organizers have given us "Special attention regions: 41-50, 100-110, 125-128." These are highlighted in Note Mode.

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 12,136
  2. Avatar for foldeRNA 2. foldeRNA 78 pts. 12,131
  3. Avatar for Beta Folders 3. Beta Folders 60 pts. 12,116
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 45 pts. 12,109
  5. Avatar for Contenders 5. Contenders 33 pts. 12,100
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 24 pts. 12,076
  7. Avatar for FoldIt@Netherlands 7. FoldIt@Netherlands 17 pts. 12,049
  8. Avatar for HMT heritage 8. HMT heritage 12 pts. 12,040
  9. Avatar for Go Science 9. Go Science 8 pts. 12,022
  10. Avatar for Deleted group 10. Deleted group pts. 12,006
  1. Avatar for crawlee34225 171. crawlee34225 Lv 1 1 pt. 11,270
  2. Avatar for Oa10712 172. Oa10712 Lv 1 1 pt. 11,262
  3. Avatar for screenshot 173. screenshot Lv 1 1 pt. 11,261
  4. Avatar for ZeroLeak7 174. ZeroLeak7 Lv 1 1 pt. 11,249
  5. Avatar for Deleted player 175. Deleted player pts. 11,230
  6. Avatar for Vie 176. Vie Lv 1 1 pt. 11,228
  7. Avatar for aspadistra 177. aspadistra Lv 1 1 pt. 11,224
  8. Avatar for impixi 178. impixi Lv 1 1 pt. 11,194
  9. Avatar for MalcolmW 179. MalcolmW Lv 1 1 pt. 11,153
  10. Avatar for flip88 180. flip88 Lv 1 1 pt. 11,122

Comments

beta_helix Staff Lv 1

Please look at the Notes for this puzzle (by pressing 3 in the Original Interface, or pressing 1 in the Selection Interface).

We recommend focusing your work on these 3 regions.

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=203

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=90. Special attention regions: 41-50, 100-110, 125-128."

GDT_TS=90 essentially means that 90% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 80-81, 94, 114-115, 123 & 134 are highly predicted to be part of a sheet. However, the Valines at residues 45, 52 & 103 are predicted to be in anything.