615 (<15): CASP10 Refinement Puzzle: TR754

Closed since over 13 years ago

Summary

• Created: August 07, 2012
• Expires: August 14, 2012 at 23:59 UTC
• Max points: 100

Description

This is the twenty-fourth CASP10 Refinement Target. This model was the best server prediction for target T0754, generated by the Zhang Server. We've been told that ~77% of this model matches the native, so you'll need to refine ~23% of the structure. Luckily, this target only has 68 residues. More info in the puzzle comments. For players with fewer than 15 global points.

Top groups

• 1. Void Crushers 100 pts. 9,188
• 2. Argentina 47 pts. 8,715
• 3. Go Science 19 pts. 8,563
• 4. Team China 7 pts. 8,356
• 5. Crunching Family 2 pts. 8,287
• 6. SETIKAH@KOREA 1 pt. 8,217
• 7. Brony@Home 1 pt. 8,173
• 8. contest winners 1 pt. 8,007

Top soloists

• 21. Doriphor 67 pts. 8,771
• 22. goracio 66 pts. 8,745
• 23. karoline314159 64 pts. 8,739
• 24. Cloud Leviathan 63 pts. 8,727
• 25. Quark150 62 pts. 8,715
• 26. fold31415 60 pts. 8,706
• 27. TheMechanicalSun 59 pts. 8,696
• 28. Littlenova7 58 pts. 8,683
• 29. dani000987 57 pts. 8,682
• 30. RyanAH 55 pts. 8,681

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=211

Note that the organizers gave us this hint:

"Starting model's GDT_TS=77."

GDT_TS=77 essentially means that ONLY 77% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...

[acalhoon]

Is it possible to see the final folds for the top 3 finishers in this category? As a novice, I think it would be very helpful to see what some winning folds look like!