Placeholder image of a protein
Icon representing a puzzle

661: Malaria Puzzle

Closed since about 13 years ago

Intermediate Overall Prediction

Summary

Created
December 17, 2012
Expires
Max points
100
Description

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 11,473
  2. Avatar for Contenders 2. Contenders 83 pts. 11,466
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 69 pts. 11,453
  4. Avatar for Beta Folders 4. Beta Folders 56 pts. 11,369
  5. Avatar for Deleted group 5. Deleted group pts. 11,347
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 36 pts. 11,337
  7. Avatar for Gargleblasters 7. Gargleblasters 29 pts. 11,320
  8. Avatar for HMT heritage 8. HMT heritage 23 pts. 11,311
  9. Avatar for Russian team 9. Russian team 18 pts. 11,289
  10. Avatar for Void Crushers 10. Void Crushers 14 pts. 11,249
  1. Avatar for BootsMcGraw 31. BootsMcGraw Lv 1 67 pts. 11,274
  2. Avatar for vakobo 32. vakobo Lv 1 67 pts. 11,273
  3. Avatar for Jim Fraser 33. Jim Fraser Lv 1 66 pts. 11,271
  4. Avatar for rcpyle77 34. rcpyle77 Lv 1 65 pts. 11,266
  5. Avatar for bendbob 35. bendbob Lv 1 64 pts. 11,264
  6. Avatar for Roukess 36. Roukess Lv 1 63 pts. 11,264
  7. Avatar for Rav3n_pl 37. Rav3n_pl Lv 1 62 pts. 11,263
  8. Avatar for montadar 38. montadar Lv 1 61 pts. 11,262
  9. Avatar for goastano 39. goastano Lv 1 60 pts. 11,260
  10. Avatar for fishercat 40. fishercat Lv 1 59 pts. 11,260

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucines at residue 11-12 & 68 are highly predicted to be part of a sheet. However, the Isoleucines at residue 34, 86 & 131 have an equal probability of being anything.

BCAA Lv 1

What kind of malaria protein is this? Isn't Malaria caused by various Plasmodium parasites? It would be interesting to know more about this task.

pauldunn Lv 1

source: http://www.uniprot.org

It matches the Reticulocyte binding protein 5 -Plasmodium falciparum (isolate 3D7)entry Q8IFM5 and Reticulocyte binding protein 5 - Plasmodium falciparum entry B2L3N7 except for an added cysteine.

BCAA Lv 1

@Paul: It wasn't clear, until I asked for the specific protein. No PfRh5 in the description. And malaria is can be caused by Plasmodium vivax, too. But only the tertiana form.

@foldit: If malaria proteins aren't determined well we should have some "Merry Christmas Malaria Folding Weeks". I mean it's still a deadly disease and there's no 100% protection against mosquito bites like protection against AIDS.

Oh and for the next puzzle descriptions, if I may ask:
If you can, please put more than 3 lines in the description. Why are we folding this specific protein? Is it promising some algorithm improvements? Or are scientific departments asking for it? It's really interesting to me and I guess for other's, too.

Thanks again.