Placeholder image of a protein
Icon representing a puzzle

675: Hydrogen-producing Catalyst Dimer (DEPRECATED)

Closed since about 13 years ago

Intermediate

Summary

Created
February 05, 2013
Expires
Max points
100
Description

This puzzle has been deprecated. Please reload your solutions in "675: Hydrogen-producing Catalyst Dimer (Fixed)"

Top groups

  1. Avatar for Davidson College Wildcats 21. Davidson College Wildcats 1 pt. 8,229
  2. Avatar for Eὕρηκα! Heureka! 22. Eὕρηκα! Heureka! 1 pt. 8,217
  3. Avatar for Deleted group 23. Deleted group pts. 7,744
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 7,482
  5. Avatar for test_group1 25. test_group1 1 pt. 7,481
  6. Avatar for Window Group 26. Window Group 1 pt. 7,432
  7. Avatar for null pointer exception 27. null pointer exception 1 pt. 7,432
  8. Avatar for Atlanta 28. Atlanta 1 pt. 7,432
  1. Avatar for Ch Garnier
    1. Ch Garnier Lv 1
    100 pts. 9,945
  2. Avatar for Alistair69 2. Alistair69 Lv 1 98 pts. 9,802
  3. Avatar for cbwest 3. cbwest Lv 1 96 pts. 9,770
  4. Avatar for Bletchley Park 4. Bletchley Park Lv 1 94 pts. 9,759
  5. Avatar for hansvandenhof 5. hansvandenhof Lv 1 92 pts. 9,759
  6. Avatar for mirp 6. mirp Lv 1 90 pts. 9,675
  7. Avatar for spdenne 7. spdenne Lv 1 88 pts. 9,607
  8. Avatar for johnmitch 8. johnmitch Lv 1 87 pts. 9,592
  9. Avatar for rcpyle77 9. rcpyle77 Lv 1 85 pts. 9,547
  10. Avatar for O Seki To 10. O Seki To Lv 1 83 pts. 9,534

Comments

jflat06 Staff Lv 1

Our two overarching goals for these hybrid catalyst/peptides: 1. put proton-donating groups like Asparagine and Histidine near the nitrogen atoms of the catalyst (to be emphasized in a follow-up puzzle), and 2. form a stable structure so strong that it freezes the catalyst in this conformation. (The catalyst is actually more flexible that it appears here - but this is the conformation it needs to adopt in order to produce hydrogen, which is why we're keeping it frozen for this design puzzle.) More details in the upcoming blog post.

arcsign Lv 1

Is there any information about which parts of the catalyst may or may not need to be exposed for it to function properly? I don't know if the term active site applies, but basically I'm wondering what the equivalent is here.

DrLemming Lv 1

Keeping the catalyst mostly buried would be great if you can manage it, but there is a spot that should have access to polar stuff: the nitrogens near the central metal. (Or the metal itself, but that's tough to get to, which is what the nitrogens are for: shuttling protons to the metal.) "Polar stuff" can be solvent, or it can be any buried polar group.

More info on the catalyst can be found here:
http://www.pnl.gov/news/release.aspx?id=883
and in the recent blog post & podcasts.

Oh, but for this puzzle, don't worry about anything besides building cool-looking, low-energy designs. :) Once we figure out the best way to give players bonuses for putting polar hydrogens near the nitrogen atoms of the catalyst, we'll give you more details about what we're looking for, and how to get the best score bonus.