Placeholder image of a protein
Icon representing a puzzle

676 (<15): 76 Residue Monomer Freestyle

Closed since about 13 years ago

Beginner Beginner

Summary

Created
February 14, 2013
Expires
Max points
100
Description

We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer.

There are four filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The 1st LayerScore filter ensures the number of residues in the core is between 30% and 70%. The 2nd LayerScore filter ensures the number of residues on the surface is between 30% and 70%. The 3rd LayerScore filter ensures the number of boundary (residues between the core and surface) residues is below 70%. We hope these filters will help you design proteins that the scientists will be able to create in the lab.

For players with fewer than 15 global points.

Top groups

  1. Avatar for Russian team
    1. Russian team
    100 pts. 10,860
  2. Avatar for Deleted group 2. Deleted group pts. 10,804
  3. Avatar for Team China 3. Team China 33 pts. 9,789
  4. Avatar for Minions of TWIS 4. Minions of TWIS 17 pts. 6,646
  5. Avatar for NTAHS 5. NTAHS 8 pts. 6,641
  6. Avatar for :) 6. :) 4 pts. 6,609
  7. Avatar for Family Style Folding 7. Family Style Folding 2 pts. 6,549
  8. Avatar for Saperska Elita 8. Saperska Elita 1 pt. 6,319
  9. Avatar for Androids 9. Androids 1 pt. 6,198
  10. Avatar for Cedarburg H.S. 10. Cedarburg H.S. 1 pt. 3,040
  1. Avatar for axabras 371. axabras Lv 1 1 pt. 4,076
  2. Avatar for Satsoc28 372. Satsoc28 Lv 1 1 pt. 4,065
  3. Avatar for DeltaEta 373. DeltaEta Lv 1 1 pt. 3,960
  4. Avatar for Synthon 374. Synthon Lv 1 1 pt. 3,956
  5. Avatar for Dre Cali 375. Dre Cali Lv 1 1 pt. 3,865
  6. Avatar for Higure Hokousha 376. Higure Hokousha Lv 1 1 pt. 3,865
  7. Avatar for lucasreisert 377. lucasreisert Lv 1 1 pt. 3,847
  8. Avatar for dheym 378. dheym Lv 1 1 pt. 3,843
  9. Avatar for itsG 379. itsG Lv 1 1 pt. 3,834
  10. Avatar for Crounus 380. Crounus Lv 1 1 pt. 3,831

Comments

tamirh Lv 1

The Layer Score filter ensures the proteins will fold up into desirable and realistic shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.