Placeholder image of a protein
Icon representing a puzzle

686: De-novo Freestyle 21

Closed since about 13 years ago

Intermediate Overall Prediction

Summary

Created
March 13, 2013
Expires
Max points
100
Description

This currently unsolved short protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

Top groups

  1. Avatar for Go Science 11. Go Science 13 pts. 9,860
  2. Avatar for foldeRNA 12. foldeRNA 10 pts. 9,821
  3. Avatar for FoldIt@Netherlands 13. FoldIt@Netherlands 7 pts. 9,722
  4. Avatar for Richard Dawkins Foundation 14. Richard Dawkins Foundation 6 pts. 9,604
  5. Avatar for SETI.Germany 15. SETI.Germany 4 pts. 9,482
  6. Avatar for Natural Abilities 16. Natural Abilities 3 pts. 9,357
  7. Avatar for Brony@Home 17. Brony@Home 2 pts. 9,348
  8. Avatar for Team Schleswig-Holstein 18. Team Schleswig-Holstein 2 pts. 9,061
  9. Avatar for Biology-4th 19. Biology-4th 1 pt. 8,887
  10. Avatar for Hydrophobic Helpers 20. Hydrophobic Helpers 1 pt. 8,844
  1. Avatar for Steven Pletsch 21. Steven Pletsch Lv 1 75 pts. 9,876
  2. Avatar for johnmitch 22. johnmitch Lv 1 74 pts. 9,870
  3. Avatar for O Seki To 23. O Seki To Lv 1 72 pts. 9,869
  4. Avatar for gramps 24. gramps Lv 1 71 pts. 9,867
  5. Avatar for steveB 25. steveB Lv 1 70 pts. 9,863
  6. Avatar for martinzblavy 26. martinzblavy Lv 1 69 pts. 9,856
  7. Avatar for spdenne 27. spdenne Lv 1 68 pts. 9,851
  8. Avatar for mirp 28. mirp Lv 1 67 pts. 9,849
  9. Avatar for jermainiac 29. jermainiac Lv 1 66 pts. 9,840
  10. Avatar for Alistair69 30. Alistair69 Lv 1 65 pts. 9,834

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 25 & 58 are highly predicted to be part of a sheet. However, the Alanines at residues 40 & 47 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

marie_s Lv 1

It is easiest that many new ones with layers.
Please put this type of puzzle in intermediate, I think new ones may have fun plying with them.

For new ones, just check you have do all these tutorials:

  • lonely sheets,
  • lock and lower,
  • rebuild,
  • structure and rebuild,
  • control over clashing.

beta_helix Staff Lv 1

I have switched it to "Intermediate" and we'll make the Design puzzles with Filters "Advanced" from now on (until we are able to make them easier!)