Placeholder image of a protein
Icon representing a puzzle

689b: Hand-Folding CASP10 T0711 Repost

Closed since almost 13 years ago

Intermediate Overall Prediction Hand-Folding

Summary

Created
March 20, 2013
Expires
Max points
100
Description

We are reposting this 33 residue CASP10 target to try out the new Disulfide Count Score Filter. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. We are again giving you the top-predicted templates from 3 different alignment programs. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 8,767
  2. Avatar for Contenders 2. Contenders 80 pts. 8,711
  3. Avatar for Beta Folders 3. Beta Folders 63 pts. 8,703
  4. Avatar for Void Crushers 4. Void Crushers 49 pts. 8,700
  5. Avatar for SETI.Germany 5. SETI.Germany 37 pts. 8,658
  6. Avatar for Natural Abilities 6. Natural Abilities 28 pts. 8,594
  7. Avatar for Gargleblasters 7. Gargleblasters 21 pts. 8,582
  8. Avatar for Go Science 8. Go Science 15 pts. 8,565
  9. Avatar for Russian team 9. Russian team 11 pts. 8,544
  10. Avatar for L'Alliance Francophone 10. L'Alliance Francophone 8 pts. 8,511
  1. Avatar for findiggle 221. findiggle Lv 1 1 pt. 7,606
  2. Avatar for beta_helix 222. beta_helix Lv 1 1 pt. 7,603
  3. Avatar for ingoneato 223. ingoneato Lv 1 1 pt. 7,553
  4. Avatar for westrel3 224. westrel3 Lv 1 1 pt. 7,497
  5. Avatar for chh9513136 225. chh9513136 Lv 1 1 pt. 7,488
  6. Avatar for rawkuts 226. rawkuts Lv 1 1 pt. 7,225
  7. Avatar for capncubensis 227. capncubensis Lv 1 1 pt. 5,000
  8. Avatar for ivalnic 228. ivalnic Lv 1 1 pt. 4,699
  9. Avatar for ianst 229. ianst Lv 1 1 pt. 4,699
  10. Avatar for Susanne 230. Susanne Lv 1 1 pt. 4,699

Comments

beta_helix Staff Lv 1

This puzzle uses the new Disulfide Count Score Filter to address some of the problems pointed out by players when this puzzle was posted during CASP10:
http://fold.it/portal/node/992993#comment-18429
__________________

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=120
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

You can see that these secondary structure predictions imply that this protein is mostly loop!
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1lu0
http://www.pdb.org/pdb/explore/explore.do?structureId=1w7z
http://www.pdb.org/pdb/explore/explore.do?structureId=1h9h

For those of you who miss your scripts, don't worry: the "normal" version of this puzzle will be reposted next week (allowing you to you to load in your manual saves from this puzzle).