Placeholder image of a protein
Icon representing a puzzle

689b: Hand-Folding CASP10 T0711 Repost

Closed since almost 13 years ago

Intermediate Overall Prediction Hand-Folding

Summary

Created
March 20, 2013
Expires
Max points
100
Description

We are reposting this 33 residue CASP10 target to try out the new Disulfide Count Score Filter. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. We are again giving you the top-predicted templates from 3 different alignment programs. More details about this CASP target are in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 8,767
  2. Avatar for Contenders 2. Contenders 80 pts. 8,711
  3. Avatar for Beta Folders 3. Beta Folders 63 pts. 8,703
  4. Avatar for Void Crushers 4. Void Crushers 49 pts. 8,700
  5. Avatar for SETI.Germany 5. SETI.Germany 37 pts. 8,658
  6. Avatar for Natural Abilities 6. Natural Abilities 28 pts. 8,594
  7. Avatar for Gargleblasters 7. Gargleblasters 21 pts. 8,582
  8. Avatar for Go Science 8. Go Science 15 pts. 8,565
  9. Avatar for Russian team 9. Russian team 11 pts. 8,544
  10. Avatar for L'Alliance Francophone 10. L'Alliance Francophone 8 pts. 8,511
  1. Avatar for Thooliv 41. Thooliv Lv 1 41 pts. 8,488
  2. Avatar for Roukess 42. Roukess Lv 1 40 pts. 8,487
  3. Avatar for mimi 43. mimi Lv 1 39 pts. 8,481
  4. Avatar for johnmitch 44. johnmitch Lv 1 38 pts. 8,472
  5. Avatar for Deleted player 45. Deleted player pts. 8,469
  6. Avatar for Double-Blind 46. Double-Blind Lv 1 36 pts. 8,468
  7. Avatar for cbwest 47. cbwest Lv 1 35 pts. 8,460
  8. Avatar for Savas 48. Savas Lv 1 34 pts. 8,454
  9. Avatar for wozzarelli 49. wozzarelli Lv 1 33 pts. 8,449
  10. Avatar for jermainiac 50. jermainiac Lv 1 33 pts. 8,446

Comments

beta_helix Staff Lv 1

This puzzle uses the new Disulfide Count Score Filter to address some of the problems pointed out by players when this puzzle was posted during CASP10:
http://fold.it/portal/node/992993#comment-18429
__________________

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=120
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

You can see that these secondary structure predictions imply that this protein is mostly loop!
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1lu0
http://www.pdb.org/pdb/explore/explore.do?structureId=1w7z
http://www.pdb.org/pdb/explore/explore.do?structureId=1h9h

For those of you who miss your scripts, don't worry: the "normal" version of this puzzle will be reposted next week (allowing you to you to load in your manual saves from this puzzle).