Placeholder image of a protein
Icon representing a puzzle

717: CASP ROLL Target R0034

Closed since almost 13 years ago

Intermediate Overall Prediction CASP ROLL

Summary

Created
May 22, 2013
Expires
Max points
100
Description

CASP ROLL started up again, but this is the first target that isn't too large for Foldit. We are giving you the 5 Rosetta Server models to work on. Resetting the puzzle will cycle through them, please try out all 5 starting points. The secondary structure predictions are provided on the extended chain in the Alignment Tool, with more details posted in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 11,357
  2. Avatar for Go Science 2. Go Science 81 pts. 11,294
  3. Avatar for Void Crushers 3. Void Crushers 65 pts. 11,278
  4. Avatar for Beta Folders 4. Beta Folders 52 pts. 11,275
  5. Avatar for Contenders 5. Contenders 41 pts. 11,254
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 32 pts. 11,229
  7. Avatar for HMT heritage 7. HMT heritage 24 pts. 11,220
  8. Avatar for Richard Dawkins Foundation 8. Richard Dawkins Foundation 18 pts. 11,219
  9. Avatar for It's over 9000! 9. It's over 9000! 14 pts. 11,217
  10. Avatar for Gargleblasters 10. Gargleblasters 10 pts. 11,202
  1. Avatar for phi16 41. phi16 Lv 1 46 pts. 11,171
  2. Avatar for CheezWhiz 42. CheezWhiz Lv 1 45 pts. 11,162
  3. Avatar for Bruno Kestemont 43. Bruno Kestemont Lv 1 44 pts. 11,161
  4. Avatar for BootsMcGraw 44. BootsMcGraw Lv 1 43 pts. 11,161
  5. Avatar for drumpeter18yrs9yrs 45. drumpeter18yrs9yrs Lv 1 42 pts. 11,160
  6. Avatar for Roukess 46. Roukess Lv 1 41 pts. 11,160
  7. Avatar for Ashrai 47. Ashrai Lv 1 40 pts. 11,156
  8. Avatar for crpainter 48. crpainter Lv 1 39 pts. 11,156
  9. Avatar for drjr 49. drjr Lv 1 38 pts. 11,156
  10. Avatar for AsDawnBreaks 50. AsDawnBreaks Lv 1 37 pts. 11,155

Comments

beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casprol/target.cgi?id=78

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 18, 54, 79 and 100 is highly predicted to be part of a helix. However, the Valine at residue 111 is not predicted to be anything!

The above predictions are already on the starting extended chain which is available in the Alignment Tool (based on the horizontal lines in the above figure).

bendbob Lv 1

The puzzle information states: "this round only GUI scripts are allowed." This is not correct I am seeing regular LUA scripts run just fine.

beta_helix Staff Lv 1

Because the Rosetta Server models do not match the secondary structure predictions, I did not want to bias you with Rosetta's structure.

The extended chain is only available in the alignment tool (for those who want it) but I did not want some players to randomly start with the extended chain if they didn't know they could reset to get a better model.
This is how we normally post CASP ROLL puzzles starting from Server Models (Puzzle 654, for example).
The extended chain does have the secondary structure predictions on it, however.

Thanks you gramps for providing that script for everyone!

beta_helix Staff Lv 1

I'm very sorry about that marie_s, I checked this before posting it, but clearly this isn't working correctly!

I'll look into what is going on, thankfully everyone can use gramps' script for now (good thing this wasn't a GUI-only round!)

dbuske Lv 1

I haven't been able to access puzzle for days.
Crashes on loading. Whole program crashes to desktop