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730: Blind Electron Density Puzzle 8

Closed since over 12 years ago

Advanced Overall Prediction Electron Density

Summary

Created
June 13, 2013
Expires
Max points
100
Description

This is another very difficult Electron Density puzzle where the automated methods were unable to solve this structure using this density. Here is another chance for you to outsmart the computers! Use all your Electron Density folding skills to fit the density as well as you can. Again, secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments.

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Comments

beta_helix Staff Lv 1

As requested in the last Scientist Chat , here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Alanines at residues 117-119, 121-122 and 130 are highly predicted to be part of a helix. However, the Alanines at residues 3 and 80 are not predicted to be anything!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
______________

Cutaway view hint:
If you hover your mouse over a segment and type shift-Q, the game will hide parts of the protein and cloud that are not in the same plane as that segment - it cuts down on how much cloud you see at one time and makes it easier to focus. Q returns to normal view.