Placeholder image of a protein
Icon representing a puzzle

730: Blind Electron Density Puzzle 8

Closed since over 12 years ago

Advanced Overall Prediction Electron Density

Summary

Created
June 13, 2013
Expires
Max points
100
Description

This is another very difficult Electron Density puzzle where the automated methods were unable to solve this structure using this density. Here is another chance for you to outsmart the computers! Use all your Electron Density folding skills to fit the density as well as you can. Again, secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 12,142
  2. Avatar for Void Crushers 2. Void Crushers 81 pts. 11,287
  3. Avatar for Contenders 3. Contenders 65 pts. 11,112
  4. Avatar for Beta Folders 4. Beta Folders 52 pts. 11,064
  5. Avatar for Go Science 5. Go Science 41 pts. 10,881
  6. Avatar for Richard Dawkins Foundation 6. Richard Dawkins Foundation 32 pts. 10,776
  7. Avatar for SETI.Germany 7. SETI.Germany 24 pts. 10,682
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 18 pts. 10,484
  9. Avatar for Gargleblasters 9. Gargleblasters 14 pts. 10,320
  10. Avatar for HMT heritage 10. HMT heritage 10 pts. 10,268
  1. Avatar for Bletchley Park 61. Bletchley Park Lv 1 26 pts. 10,067
  2. Avatar for frood66 62. frood66 Lv 1 25 pts. 10,054
  3. Avatar for Jim Fraser 63. Jim Fraser Lv 1 25 pts. 10,024
  4. Avatar for Franco Padelletti 64. Franco Padelletti Lv 1 24 pts. 10,022
  5. Avatar for Grom 65. Grom Lv 1 23 pts. 10,019
  6. Avatar for smilingone 66. smilingone Lv 1 23 pts. 10,014
  7. Avatar for SKSbell 67. SKSbell Lv 1 22 pts. 10,001
  8. Avatar for jermainiac 68. jermainiac Lv 1 22 pts. 9,998
  9. Avatar for retiredmichael 69. retiredmichael Lv 1 21 pts. 9,984
  10. Avatar for Alistair69 70. Alistair69 Lv 1 21 pts. 9,929

Comments

beta_helix Staff Lv 1

As requested in the last Scientist Chat , here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Alanines at residues 117-119, 121-122 and 130 are highly predicted to be part of a helix. However, the Alanines at residues 3 and 80 are not predicted to be anything!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
______________

Cutaway view hint:
If you hover your mouse over a segment and type shift-Q, the game will hide parts of the protein and cloud that are not in the same plane as that segment - it cuts down on how much cloud you see at one time and makes it easier to focus. Q returns to normal view.