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731b: Unsolved Chicken Anemia Virus Protein

Closed since over 12 years ago

Intermediate Overall Prediction

Summary

Created
June 19, 2013
Expires
Max points
100
Description

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

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Comments

beta_helix Staff Lv 1

We've added the Disulfide Count Score Filter to Puzzle 731.

The new Disulfide Count Score Filter gives you a bonus for forming bridges. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them.

You will be able to load in your manual saves from 731 into this puzzle. If you did not manually save a solution in puzzle 731, you can go back to 731, manually save it, and the solution should appear in your manual saves for this puzzle, 731b.

Here is the original puzzle, with the motivation for why we reposted it:
http://fold.it/portal/node/995342#comment-23494

brow42 Lv 1

If you enable the filter on a puzzle, that means the players will try to make as many bridges as they can. What if some don't exist, or exist to another molecule not in the puzzle? A 100 point bonus can cover up a lot of unnatural contortions to make that bridge. I'd rather not have the filter enabled, unless the scientists are certain that every cysteine is part of a bridge, like in a knot.

beta_helix Staff Lv 1

You will not get an extra bonus for forming more bridges than they recommend.
We are able to set the bonus for the range of bridges we want (and in fact can penalize for too many bridges if we need to).
_____________

The Worcester Polytechnic Institute Scientists have also answered another question in the feedback:
http://fold.it/portal/node/995388