Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Geekdo 11. Geekdo 2 pts. 10,560
  2. Avatar for Mojo Risin' 12. Mojo Risin' 1 pt. 10,553
  3. Avatar for SETIKAH@KOREA 13. SETIKAH@KOREA 1 pt. 10,529
  4. Avatar for Deleted group 14. Deleted group pts. 10,237
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 10,237
  6. Avatar for Chaotropic Mutalisk 16. Chaotropic Mutalisk 1 pt. 10,088
  7. Avatar for Window Group 17. Window Group 1 pt. 9,408
  8. Avatar for ricg test group 18. ricg test group 1 pt. 8,594
  9. Avatar for Deleted group 19. Deleted group pts. 8,594
  1. Avatar for guyot0271 151. guyot0271 Lv 1 12 pts. 10,557
  2. Avatar for finn11 152. finn11 Lv 1 12 pts. 10,556
  3. Avatar for calgone 153. calgone Lv 1 12 pts. 10,554
  4. Avatar for eltosianKadatth 154. eltosianKadatth Lv 1 11 pts. 10,554
  5. Avatar for TheOmnipotentMoleRat 155. TheOmnipotentMoleRat Lv 1 11 pts. 10,554
  6. Avatar for maxionwimps 156. maxionwimps Lv 1 11 pts. 10,554
  7. Avatar for orielg 157. orielg Lv 1 11 pts. 10,554
  8. Avatar for Tlaloc 158. Tlaloc Lv 1 11 pts. 10,553
  9. Avatar for taisuke117 159. taisuke117 Lv 1 10 pts. 10,553
  10. Avatar for KegM4n 160. KegM4n Lv 1 10 pts. 10,553

Comments

beta_helix Staff Lv 1

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

  • try all puzzles not only "Beginners" ones,
  • fold first the ones you like the most,
  • try it by yourself to understand what works and what doesn't,
  • ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

  • Lonely Sheets,
  • Lock and Lower,
  • Rebuild,
  • Structure and Rebuild,
  • Movin' Along,
  • Control over Clashing,
  • Intro to Design,
  • Swappin' Sidechains,
  • Mass Mutate,
  • Insertion and Deletion

before starting this puzzle.