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Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Geekdo 11. Geekdo 2 pts. 10,560
  2. Avatar for Mojo Risin' 12. Mojo Risin' 1 pt. 10,553
  3. Avatar for SETIKAH@KOREA 13. SETIKAH@KOREA 1 pt. 10,529
  4. Avatar for Deleted group 14. Deleted group pts. 10,237
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 10,237
  6. Avatar for Chaotropic Mutalisk 16. Chaotropic Mutalisk 1 pt. 10,088
  7. Avatar for Window Group 17. Window Group 1 pt. 9,408
  8. Avatar for ricg test group 18. ricg test group 1 pt. 8,594
  9. Avatar for Deleted group 19. Deleted group pts. 8,594
  1. Avatar for MSLOVELYLADE 291. MSLOVELYLADE Lv 1 1 pt. 10,249
  2. Avatar for Shelena 292. Shelena Lv 1 1 pt. 10,247
  3. Avatar for deadlygorilla 293. deadlygorilla Lv 1 1 pt. 10,245
  4. Avatar for bsanto 294. bsanto Lv 1 1 pt. 10,244
  5. Avatar for pdines1944 295. pdines1944 Lv 1 1 pt. 10,244
  6. Avatar for chrisb41 296. chrisb41 Lv 1 1 pt. 10,244
  7. Avatar for JanTelefon 297. JanTelefon Lv 1 1 pt. 10,244
  8. Avatar for Dakirah 298. Dakirah Lv 1 1 pt. 10,242
  9. Avatar for Frowning Buddha 299. Frowning Buddha Lv 1 1 pt. 10,240
  10. Avatar for Vulcans Anvil 300. Vulcans Anvil Lv 1 1 pt. 10,238

Comments

beta_helix Staff Lv 1

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

  • try all puzzles not only "Beginners" ones,
  • fold first the ones you like the most,
  • try it by yourself to understand what works and what doesn't,
  • ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

  • Lonely Sheets,
  • Lock and Lower,
  • Rebuild,
  • Structure and Rebuild,
  • Movin' Along,
  • Control over Clashing,
  • Intro to Design,
  • Swappin' Sidechains,
  • Mass Mutate,
  • Insertion and Deletion

before starting this puzzle.