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Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

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  2. Avatar for Mojo Risin' 12. Mojo Risin' 1 pt. 10,553
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  4. Avatar for Deleted group 14. Deleted group pts. 10,237
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  5. Avatar for cgbriggs 55. cgbriggs Lv 1 51 pts. 10,620
  6. Avatar for Daishi 56. Daishi Lv 1 51 pts. 10,619
  7. Avatar for Skippysk8s 57. Skippysk8s Lv 1 50 pts. 10,619
  8. Avatar for twyla2007 58. twyla2007 Lv 1 49 pts. 10,619
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  10. Avatar for dav1d_kennedy 60. dav1d_kennedy Lv 1 48 pts. 10,617

Comments

beta_helix Staff Lv 1

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

  • try all puzzles not only "Beginners" ones,
  • fold first the ones you like the most,
  • try it by yourself to understand what works and what doesn't,
  • ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

  • Lonely Sheets,
  • Lock and Lower,
  • Rebuild,
  • Structure and Rebuild,
  • Movin' Along,
  • Control over Clashing,
  • Intro to Design,
  • Swappin' Sidechains,
  • Mass Mutate,
  • Insertion and Deletion

before starting this puzzle.