Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 10,738
  2. Avatar for HMT heritage 2. HMT heritage 76 pts. 10,730
  3. Avatar for Gargleblasters 3. Gargleblasters 56 pts. 10,727
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 41 pts. 10,684
  5. Avatar for Eὕρηκα! Heureka! 5. Eὕρηκα! Heureka! 29 pts. 10,672
  6. Avatar for Curtin Crowd 6. Curtin Crowd 20 pts. 10,628
  7. Avatar for Crunching Family 7. Crunching Family 14 pts. 10,628
  8. Avatar for Repro-men 8. Repro-men 9 pts. 10,619
  9. Avatar for Czech National Team 9. Czech National Team 6 pts. 10,607
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 4 pts. 10,579
  1. Avatar for alisoni 241. alisoni Lv 1 2 pts. 10,482
  2. Avatar for jftkmo 242. jftkmo Lv 1 2 pts. 10,482
  3. Avatar for catgirl11 243. catgirl11 Lv 1 2 pts. 10,482
  4. Avatar for Bart from the Sea 244. Bart from the Sea Lv 1 2 pts. 10,477
  5. Avatar for Wheeler22 245. Wheeler22 Lv 1 2 pts. 10,476
  6. Avatar for Mathian628 246. Mathian628 Lv 1 2 pts. 10,476
  7. Avatar for heiheihei231945 247. heiheihei231945 Lv 1 2 pts. 10,474
  8. Avatar for peter_cb 248. peter_cb Lv 1 2 pts. 10,473
  9. Avatar for TheSequelReturns 249. TheSequelReturns Lv 1 2 pts. 10,472
  10. Avatar for AlexHighScoreGamer 250. AlexHighScoreGamer Lv 1 2 pts. 10,471

Comments

beta_helix Staff Lv 1

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

  • try all puzzles not only "Beginners" ones,
  • fold first the ones you like the most,
  • try it by yourself to understand what works and what doesn't,
  • ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

  • Lonely Sheets,
  • Lock and Lower,
  • Rebuild,
  • Structure and Rebuild,
  • Movin' Along,
  • Control over Clashing,
  • Intro to Design,
  • Swappin' Sidechains,
  • Mass Mutate,
  • Insertion and Deletion

before starting this puzzle.