Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary


Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for BOINC@Poland 11. BOINC@Poland 35 pts. 10,639
  2. Avatar for IB Biology 12. IB Biology 31 pts. 10,622
  3. Avatar for DNA Masters 13. DNA Masters 27 pts. 10,606
  4. Avatar for CSC337 Bio 14. CSC337 Bio 24 pts. 10,606
  5. Avatar for Anthropic Dreams 15. Anthropic Dreams 21 pts. 10,600
  6. Avatar for DSN @ Home 16. DSN @ Home 19 pts. 10,596
  7. Avatar for ISU BCB 544 Foldit! 17. ISU BCB 544 Foldit! 16 pts. 10,594
  8. Avatar for Curtin Crowd 18. Curtin Crowd 14 pts. 10,590
  9. Avatar for Deleted group 20. Deleted group pts. 10,575

  1. Avatar for balb26 81. balb26 Lv 1 72 pts. 10,635
  2. Avatar for farhawk3 82. farhawk3 Lv 1 72 pts. 10,634
  3. Avatar for TheNinja 83. TheNinja Lv 1 71 pts. 10,634
  4. Avatar for BioRagunia 84. BioRagunia Lv 1 71 pts. 10,633
  5. Avatar for Jewelius 85. Jewelius Lv 1 71 pts. 10,632
  6. Avatar for GRandall64 86. GRandall64 Lv 1 70 pts. 10,632
  7. Avatar for jaybob20 87. jaybob20 Lv 1 70 pts. 10,632
  8. Avatar for Sequim.Fanestil.3 88. Sequim.Fanestil.3 Lv 1 70 pts. 10,630
  9. Avatar for foldthestuffman 89. foldthestuffman Lv 1 69 pts. 10,630
  10. Avatar for nbrownjr 90. nbrownjr Lv 1 69 pts. 10,630

Comments