Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary


Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for FoldIt@Netherlands 31. FoldIt@Netherlands 2 pts. 10,552
  2. Avatar for Team Aquidneck Island 32. Team Aquidneck Island 2 pts. 10,551
  3. Avatar for Brony@Home 33. Brony@Home 1 pt. 10,549
  4. Avatar for Boinc.be 34. Boinc.be 1 pt. 10,543
  5. Avatar for Team South Africa 35. Team South Africa 1 pt. 10,527
  6. Avatar for Cancer Blasters! 36. Cancer Blasters! 1 pt. 10,521
  7. Avatar for The Rock 37. The Rock 1 pt. 10,512
  8. Avatar for Hydrophobic Helpers 38. Hydrophobic Helpers 1 pt. 10,490
  9. Avatar for Adams Genetics 1 39. Adams Genetics 1 1 pt. 10,485
  10. Avatar for The Minecrafters 40. The Minecrafters 1 pt. 10,371

  1. Avatar for Chip otob 11. Chip otob Lv 1 96 pts. 10,698
  2. Avatar for heyubob 12. heyubob Lv 1 96 pts. 10,698
  3. Avatar for oureion 13. oureion Lv 1 96 pts. 10,698
  4. Avatar for RSHolt 14. RSHolt Lv 1 95 pts. 10,694
  5. Avatar for informator 15. informator Lv 1 95 pts. 10,694
  6. Avatar for BackupElk 16. BackupElk Lv 1 95 pts. 10,693
  7. Avatar for larry25427 17. larry25427 Lv 1 94 pts. 10,692
  8. Avatar for gardenpea 18. gardenpea Lv 1 94 pts. 10,691
  9. Avatar for dzagal 19. dzagal Lv 1 93 pts. 10,690
  10. Avatar for gordon_quad 20. gordon_quad Lv 1 93 pts. 10,688

Comments