Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Ranger's AP Bio 13-14 41. Ranger's AP Bio 13-14 1 pt. 10,352
  2. Avatar for Fold for Science 1 42. Fold for Science 1 1 pt. 10,243
  3. Avatar for Aviation High School 43. Aviation High School 1 pt. 10,240
  4. Avatar for Team Germany 44. Team Germany 1 pt. 10,237
  5. Avatar for OS CBIO 45. OS CBIO 1 pt. 10,212
  6. Avatar for Richard Dawkins Foundation 46. Richard Dawkins Foundation 1 pt. 10,182
  7. Avatar for Team China 47. Team China 1 pt. 10,153
  8. Avatar for Rice Biochemistry 48. Rice Biochemistry 1 pt. 10,151
  9. Avatar for chem 1105 49. chem 1105 1 pt. 8,594
  10. Avatar for (no name) 50. (no name) 1 pt. 8,594
  1. Avatar for Teri VL 961. Teri VL Lv 1 1 pt. 10,081
  2. Avatar for Lucius Gold 962. Lucius Gold Lv 1 1 pt. 10,081
  3. Avatar for kEnder242 963. kEnder242 Lv 1 1 pt. 10,079
  4. Avatar for TRex8484 964. TRex8484 Lv 1 1 pt. 10,067
  5. Avatar for Deoxy 965. Deoxy Lv 1 1 pt. 10,063
  6. Avatar for sabi-na 966. sabi-na Lv 1 1 pt. 10,056
  7. Avatar for Travis Lott 967. Travis Lott Lv 1 1 pt. 10,053
  8. Avatar for Facerace 968. Facerace Lv 1 1 pt. 10,052
  9. Avatar for Byuda 969. Byuda Lv 1 1 pt. 10,052
  10. Avatar for rope09 970. rope09 Lv 1 1 pt. 10,048

Comments