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Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary


Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for UTD3361_F2013 51. UTD3361_F2013 1 pt. 8,594
  2. Avatar for Window Group 52. Window Group 1 pt. 8,594
  3. Avatar for Folding on Linux 53. Folding on Linux 1 pt. 8,594

  1. Avatar for jereiniger 1121. jereiniger Lv 1 1 pt. 8,594
  2. Avatar for nicoangela 1122. nicoangela Lv 1 1 pt. 8,594
  3. Avatar for tsmith108 1123. tsmith108 Lv 1 1 pt. 8,594
  4. Avatar for ewaufe 1124. ewaufe Lv 1 1 pt. 8,594
  5. Avatar for jduong28 1125. jduong28 Lv 1 1 pt. 8,594
  6. Avatar for HaydenP1995 1126. HaydenP1995 Lv 1 1 pt. 8,594
  7. Avatar for Attitude2Go 1127. Attitude2Go Lv 1 1 pt. 8,594
  8. Avatar for cleansnyder 1128. cleansnyder Lv 1 1 pt. 8,594
  9. Avatar for Kendaa 1129. Kendaa Lv 1 1 pt. 8,594
  10. Avatar for TRAUTALIS2013 1130. TRAUTALIS2013 Lv 1 1 pt. 8,594

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