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Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary


Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


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  1. Avatar for perso 811. perso Lv 1 1 pt. 10,208
  2. Avatar for theengineer0499 812. theengineer0499 Lv 1 1 pt. 10,208
  3. Avatar for marianne.mh 813. marianne.mh Lv 1 1 pt. 10,206
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  6. Avatar for ckshpik42 816. ckshpik42 Lv 1 1 pt. 10,203
  7. Avatar for mashka4foldit 817. mashka4foldit Lv 1 1 pt. 10,202
  8. Avatar for aember 818. aember Lv 1 1 pt. 10,199
  9. Avatar for a5hm0r 819. a5hm0r Lv 1 1 pt. 10,199
  10. Avatar for Dmarl 820. Dmarl Lv 1 1 pt. 10,196

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