Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary


Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for UTD3361_F2013 51. UTD3361_F2013 1 pt. 8,594
  2. Avatar for Window Group 52. Window Group 1 pt. 8,594
  3. Avatar for Folding on Linux 53. Folding on Linux 1 pt. 8,594

  1. Avatar for clarearm 921. clarearm Lv 1 1 pt. 10,144
  2. Avatar for YOUNGGABR2013 922. YOUNGGABR2013 Lv 1 1 pt. 10,143
  3. Avatar for rmh0013 923. rmh0013 Lv 1 1 pt. 10,143
  4. Avatar for SandeMada2013 924. SandeMada2013 Lv 1 1 pt. 10,142
  5. Avatar for s.vanderaa 925. s.vanderaa Lv 1 1 pt. 10,139
  6. Avatar for Gris22075 926. Gris22075 Lv 1 1 pt. 10,138
  7. Avatar for sheenaaa 927. sheenaaa Lv 1 1 pt. 10,136
  8. Avatar for Ian12 928. Ian12 Lv 1 1 pt. 10,135
  9. Avatar for reza19 929. reza19 Lv 1 1 pt. 10,134
  10. Avatar for DutchGirl 930. DutchGirl Lv 1 1 pt. 10,132

Comments