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801: Abeta Binder Redesign

Closed since over 12 years ago

Intermediate

Summary

Created
October 28, 2013
Expires
Max points
100
Description

In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!

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Comments

Mike Cassidy Lv 1

The two different Exploration multiples are for the two different parts? Just making sure I understand what is there.

bkoep Staff Lv 1

The starting model of the binding protein is a dimer of two nearly-identical chains. There is an RMSD filter for each chain of the binding protein.

I apologize that we could not label each filter for its corresponding chain.

wisky Lv 1

Seems the only way to get a decent score on this puzzle is to place arginines all across the outside of the helices. Something just seems off about it.