Placeholder image of a protein
Icon representing a puzzle

807: De-novo Cryo-electron Density: Hand-folding Round

Closed since over 12 years ago

Advanced Advanced Overall Overall Prediction Prediction Electron Density Electron Density Hand-Folding Hand-Folding

Summary

Created
November 07, 2013
Expires
Max points
100
Description

Try to fit this extended chain into the cryo-EM density cloud to gain points. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

Top groups

  1. Avatar for Crunching Family 21. Crunching Family 1 pt. 2,495
  2. Avatar for (no name) 22. (no name) 1 pt. 2,298
  3. Avatar for Brony@Home 23. Brony@Home 1 pt. 0
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 0
  5. Avatar for Team Schleswig-Holstein 25. Team Schleswig-Holstein 1 pt. 0
  1. Avatar for Crossed Sticks 81. Crossed Sticks Lv 1 20 pts. 4,948
  2. Avatar for KingLear 82. KingLear Lv 1 19 pts. 4,925
  3. Avatar for Frowning Buddha 83. Frowning Buddha Lv 1 19 pts. 4,905
  4. Avatar for KellyM695 84. KellyM695 Lv 1 18 pts. 4,875
  5. Avatar for Incongruous 85. Incongruous Lv 1 18 pts. 4,860
  6. Avatar for Icearstorm 86. Icearstorm Lv 1 17 pts. 4,856
  7. Avatar for oureion 87. oureion Lv 1 17 pts. 4,853
  8. Avatar for Vman 88. Vman Lv 1 17 pts. 4,851
  9. Avatar for mirjamvandelft 89. mirjamvandelft Lv 1 16 pts. 4,837
  10. Avatar for Reductone 90. Reductone Lv 1 16 pts. 4,835

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 41-42 are highly predicted to be part of a helix. However, the Valines at residue 67 and 94 are predicted to be in sheets!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
_________________

More info about Cryo-electron microscopy here: